Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.43 |
| ▸ | EGFR | P00533 | 11/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2960500 | 0.90 | IGF1R (0.54) | IGF1RERBB2EGFRCYP2D6 | |
| SCHEMBL2966954 | 0.80 | IGF1R (0.61) | IGF1RERBB2EGFRCYP2D6 | |
| SCHEMBL2962295 | 0.79 | IGF1R (0.65) | IGF1RERBB2EGFRCYP2D6KDR | |
| SCHEMBL2958806 | 0.77 | IGF1R (0.53) | IGF1RERBB2EGFRCYP2D6 | |
| SCHEMBL2962604 | 0.76 | IGF1R (0.73) | IGF1RERBB2EGFRCYP2D6 | |
| SCHEMBL2963573 | 0.76 | IGF1R (0.73) | IGF1RERBB2EGFRCYP2D6 | |
| SCHEMBL2962607 | 0.76 | IGF1R (0.73) | IGF1RERBB2EGFRCYP2D6 | |
| SCHEMBL2959561 | 0.70 | IGF1R (0.61) | IGF1RERBB2EGFR | |
| SCHEMBL2968808 | 0.70 | IGF1R (0.60) | IGF1RERBB2EGFR | |
| SCHEMBL2967036 | 0.70 | IGF1R (0.59) | IGF1RERBB2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973917-A2 | PROTEIN KINASE INHIBITORS | Abbott Laboratories (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007079164-A2 | PROTEIN KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2007-07-12 | — | — | WO | disclosed |