Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 12/20 | 0.49 |
| ▸ | KDM6B | O15054 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17746099 | 0.98 | KDM4C (0.47) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| SCHEMBL28188823 | 0.85 | KDM4C (0.53) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| SCHEMBL2770960 | 0.85 | SIRT3 (0.61) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| SCHEMBL27712937 | 0.84 | KDM4C (0.46) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| Hydrochloric Acid SCHEMBL15973577 | 0.83 | KDM4C (0.52) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| SCHEMBL27713021 | 0.83 | TDP1 (0.42) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| SCHEMBL7393208 | 0.82 | TDP1 (0.39) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| Potassium Ion SCHEMBL17746100 | 0.81 | TDP1 (0.41) | KDM4CKDM6BALDH1A1KDM4DKDM4E | |
| SCHEMBL3451540 | 0.79 | SIRT3 (0.39) | ALDH1A1TDP1MAPTSIRT3GAA | |
| SCHEMBL28499412 | 0.79 | TDP1 (0.39) | KDM4CKDM6BALDH1A1KDM4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | claimed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | claimed |
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| CN-101073781-A | 4-dimethy-pyridine organic molecular-catalyst containing dinaphthalene chiral functional based and its production | UNIV TIANJIN (CN) | 2007-11-21 | — | — | CN | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |