Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2937583 | 0.84 | EGFR (0.41) | MAPTGRM5ALDH1A1HTTPDE3B | |
| SCHEMBL4428327 | 0.76 | USP30 (0.40) | MAPTGRM5ALDH1A1HTTPDE3B | |
| SCHEMBL105404 | 0.73 | CYP3A4 (0.47) | MAPTALDH1A1HTTLMNAMEN1 | |
| SCHEMBL5744126 | 0.68 | CTNNB1 (0.42) | ALDH1A1NOTUMCYP3A4 | |
| SCHEMBL5140598 | 0.67 | GRM5 (0.37) | MAPTGRM5ALDH1A1HTTPDE3B | |
| SCHEMBL4440734 | 0.67 | HRH2 (0.42) | ALDH1A1 | |
| SCHEMBL844057 | 0.63 | CYP3A4 (0.39) | ALDH1A1CYP3A4 | |
| SCHEMBL30412730 | 0.63 | EGFR (0.43) | MAPTGRM5ALDH1A1HTTPDE3B | |
| SCHEMBL12405532 | 0.63 | EGFR (0.43) | MAPTGRM5THRBNOTUM | |
| SCHEMBL12405526 | 0.63 | EGFR (0.43) | MAPTGRM5THRBNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001887-A1 | PYRROLO-QUINOXALINONE DERIVATIVES AS ANTIBACTERIALS | Glaxo Group Limited (GB) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007115947-A1 | PYRROLO-QUINOXALINONE DERIVATIVES AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2007-10-18 | — | — | WO | disclosed |