Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 7/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826628 | 0.91 | SMN1; SMN2 (0.49) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2826896 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2825388 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2833439 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2831518 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL14237302 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2829014 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2828577 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2828606 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHROPRM1LMNAOPRD1 | |
| SCHEMBL2830500 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHROPRM1LMNAOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410988-B2 | 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | GENENTECH, INC. (US) | 2008-08-12 | — | — | US | claimed |