Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 6/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | DAGLB | Q8NCG7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185999 | 0.90 | CHRM2 (0.39) | HPGDTSHRDPP4DPP7DPP8 | |
| SCHEMBL6234921 | 0.84 | DPP4 (0.39) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL3526616 | 0.84 | DPP4 (0.39) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL3601162 | 0.84 | DPP4 (0.39) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL3642777 | 0.81 | GRM5 (0.36) | HPGDDPP7GAACPT1A | |
| SCHEMBL1198458 | 0.79 | PTPN2 (0.47) | HPGDPTPN1 | |
| SCHEMBL6231704 | 0.77 | — | — | |
| SCHEMBL26928055 | 0.74 | CHRM2 (0.57) | — | |
| SCHEMBL22231460 | 0.73 | GAA (0.51) | HPGDMEN1KMT2ASMN1; SMN2DPP4 | |
| SCHEMBL22231458 | 0.73 | GAA (0.51) | HPGDMEN1KMT2ASMN1; SMN2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984331-A1 | PYRROLIDINE DERIVATIVES AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007097937-A1 | PYRROLIDINE DERIVATIVES AS ERK INHIBITORS | SCHERING CORPORATION (US) | 2007-08-30 | — | — | WO | disclosed |