Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.59 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.59 |
| ▸ | WNT3A | P56704 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL402922 | 0.92 | HIF1A (0.63) | HIF1AEPAS1WNT3ARAB9ANPC1 | |
| SCHEMBL4968364 | 0.91 | MCHR1 (0.49) | HIF1AEPAS1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL4968510 | 0.89 | MAPK7 (0.52) | HIF1AEPAS1WNT3ARAB9AFLT3 | |
| SCHEMBL404278 | 0.82 | MAPT (0.52) | HIF1AEPAS1RAB9ANPC1LMNA | |
| SCHEMBL1018345 | 0.82 | KCNH2 (0.60) | HIF1AEPAS1RAB9ANPC1KMT2A | |
| SCHEMBL4973956 | 0.81 | SMO (0.47) | HIF1AEPAS1RAB9ANPC1KMT2A | |
| SCHEMBL4973693 | 0.81 | MAPK7 (0.50) | HIF1AEPAS1FLT3LMNA | |
| SCHEMBL401260 | 0.81 | PAICS (0.56) | HIF1AEPAS1WNT3AFLT3LMNA | |
| SCHEMBL4971496 | 0.80 | SMN1; SMN2 (0.47) | HIF1AEPAS1RAB9ANPC1KMT2A | |
| SCHEMBL10238341 | 0.79 | HIF1A (0.71) | HIF1AEPAS1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957461-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | Genentech, Inc. (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007059157-A1 | BISAMIDE INHIBITORS OF HEDGEHOG SIGNALING | GENENTECH, INC. (US) | 2007-05-24 | — | — | WO | claimed |