Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.32 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | IDE | P14735 | 1/20 | 0.32 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.32 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.32 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5902803 | 0.87 | CYP2C9 (0.51) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL4099809 | 0.87 | CYP2C9 (0.51) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL4099808 | 0.87 | CYP2C9 (0.51) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL5599122 | 0.84 | CYP2C9 (0.41) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL5599127 | 0.84 | CYP2C9 (0.41) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL3230226 | 0.77 | CYP2C9 (0.58) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL29267513 | 0.76 | CYP2C9 (0.47) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 | |
| SCHEMBL1902373 | 0.76 | CYP2C9 (0.37) | CYP2C9NPSR1MEN1KMT2AMAPT | |
| SCHEMBL1902370 | 0.76 | CYP2C9 (0.37) | CYP2C9NPSR1MEN1KMT2AMAPT | |
| SCHEMBL2480742 | 0.75 | CYP2C9 (0.46) | CYP2C9NPSR1GLO1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006073361-A9 | NOVEL PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |