Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 3/20 | 0.50 |
| ▸ | BTK | Q06187 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 9/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.41 |
| ▸ | PLK4 | O00444 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | INSR | P06213 | 3/20 | 0.41 |
| ▸ | FYN | P06241 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | LYN | P07948 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527042 | 0.84 | KDR (0.49) | EPHB4BTKKDRAURKBPLK4 | |
| SCHEMBL3531001 | 0.77 | EPHB4 (0.64) | EPHB4BTKKDRAURKBPLK4 | |
| SCHEMBL3532343 | 0.72 | KDR (0.49) | BTKKDRAURKBPLK4AURKA | |
| SCHEMBL3528947 | 0.71 | KDR (0.64) | BTKKDRAURKBPLK4AURKA | |
| SCHEMBL3529496 | 0.69 | KDR (0.79) | BTKKDRAURKBPLK4AURKA | |
| SCHEMBL6422862 | 0.69 | BTK (0.50) | BTKKDRAURKBPLK4AURKA | |
| SCHEMBL27640624 | 0.69 | BTK (0.50) | BTKKDRAURKBPLK4AURKA | |
| SCHEMBL3535652 | 0.69 | KDR (0.50) | EPHB4BTKKDRAURKBPLK4 | |
| SCHEMBL3530154 | 0.69 | KDR (0.52) | EPHB4BTKKDRAURKBPLK4 | |
| SCHEMBL6422548 | 0.68 | KDR (0.55) | BTKKDRAURKBPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648905-B1 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS | ABBOTT LAB (US) | 2008-12-31 | — | — | EP | disclosed |