Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5125573 | 0.99 | TRPV1 (0.43) | TRPV1KITF2F10PRSS1 | |
| Hydrochloric Acid SCHEMBL5129967 | 0.99 | TRPV1 (0.43) | TRPV1KITF2F10PRSS1 | |
| SCHEMBL16175745 | 0.75 | TRPV1 (0.53) | TRPV1 | |
| SCHEMBL5065839 | 0.74 | TRPV1 (0.51) | TRPV1 | |
| SCHEMBL5065842 | 0.74 | TRPV1 (0.51) | TRPV1 | |
| SCHEMBL5014394 | 0.72 | TRPV1 (0.64) | TRPV1 | |
| SCHEMBL30700119 | 0.72 | TRPV1 (0.37) | TRPV1KITGLO1 | |
| SCHEMBL5012886 | 0.72 | FASN (0.46) | TRPV1 | |
| SCHEMBL5139252 | 0.71 | TRPV1 (0.45) | TRPV1 | |
| SCHEMBL5014446 | 0.71 | TRPV1 (0.57) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | disclosed |