Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015719 | 0.82 | KMT2A (0.53) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2829137 | 0.79 | TSHR (0.77) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2826329 | 0.71 | TSHR (0.72) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2833510 | 0.71 | KMT2A (0.77) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2828585 | 0.71 | TSHR (0.76) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2830954 | 0.70 | TSHR (0.63) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2829988 | 0.69 | TSHR (0.81) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2827744 | 0.66 | TSHR (0.57) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2826671 | 0.66 | TSHR (0.57) | TSHRMAPK1ATMMAPTSMN1; SMN2 | |
| SCHEMBL2826515 | 0.66 | TSHR (0.57) | TSHRMAPK1ATMMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410988-B2 | 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof | GENENTECH, INC. (US) | 2008-08-12 | — | — | US | claimed |