⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16640500 | 0.81 | MEN1 (0.46) | — | |
| SCHEMBL29924283 | 0.79 | RHEB (0.52) | — | |
| SCHEMBL6206121 | 0.79 | RHEB (0.52) | — | |
| SCHEMBL16890555 | 0.77 | RHEB (0.50) | — | |
| SCHEMBL1855228 | 0.77 | — | — | |
| SCHEMBL10715309 | 0.75 | MAPT (0.54) | — | |
| SCHEMBL8124927 | 0.75 | — | — | |
| SCHEMBL31253853 | 0.75 | — | — | |
| SCHEMBL535619 | 0.75 | — | — | |
| SCHEMBL6688360 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353144-B2 | Vascular leakage inhibitor | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2016-05-31 | — | — | US | disclosed |
| US-9353144-B2 | Vascular leakage inhibitor | INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY (KR) | 2016-05-31 | — | — | US | disclosed |
| WO-2016023826-A1 | QUINAZOLINE-2,4(1H,3H)-DIONE DERIVATIVES AS TRCP5 MODULATORS FOR THE TREATMENT OF NEUROPSYCHIATRY DISORDERS | HYDRA BIOSCIENCES, INC. (US) | 2016-02-18 | — | — | WO | disclosed |
| US-20140378399-A1 | NOVEL VASCULAR LEAKAGEAGE INHIBITOR | CURACLE CO., LTD. (KR) | 2014-12-25 | — | — | US | disclosed |
| US-20140378399-A1 | NOVEL VASCULAR LEAKAGEAGE INHIBITOR | CURACLE CO., LTD. (KR) | 2014-12-25 | — | — | US | disclosed |
| US-7419962-B2 | 3,6-bicyclolides | ENANTA PHARMACEUTICALS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7229972-B2 | Semisynthetic trimethylenedioxy-erythromycin derivatives and their use in treating bacterial infections and cystic fibrosis; preparation | ENANTA PHARMACEUTICALS, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| US-20060142214-A1 | 3,6-bicyclolides | ENANTA PHARMACEUTICALS, INC. | 2006-06-29 | — | — | US | disclosed |
| US-20060122128-A1 | 3,6-Bicyclolides | ENANTA PHARMACEUTICALS, INC. | 2006-06-08 | — | — | US | disclosed |
| EP-0119892-A1 | Hydroxyl amine derivatives, their preparation, their use as growth factors for vegetables and compositions thereof | ROUSSEL-UCLAF (FR) | 1984-09-26 | — | — | EP | disclosed |