Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 16/20 | 0.59 |
| ▸ | CHUK | O15111 | 5/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL552028 | 0.89 | IKBKB (0.60) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL551599 | 0.89 | IKBKB (0.66) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL552981 | 0.87 | IKBKB (0.70) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL551378 | 0.86 | IKBKB (0.67) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL551885 | 0.85 | IKBKB (0.68) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL551828 | 0.85 | IKBKB (0.67) | IKBKBCHUKAURKAFLT3CSNK1E | |
| Trifluoroacetic Acid SCHEMBL551953 | 0.84 | IKBKB (0.62) | IKBKBCHUKAURKAFLT3CSNK1E | |
| Trifluoroacetic Acid SCHEMBL553269 | 0.82 | IKBKB (0.65) | IKBKBCHUKAURKAFLT3CSNK1E | |
| Trifluoroacetic Acid SCHEMBL552156 | 0.82 | IKBKB (0.63) | IKBKBCHUKAURKAFLT3CSNK1E | |
| Trifluoroacetic Acid SCHEMBL551594 | 0.81 | IKBKB (0.64) | IKBKBCHUKAURKAFLT3CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896014-A2 | CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007005534-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-11 | — | — | WO | disclosed |