Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 13/20 | 0.52 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
| ▸ | TYK2 | P29597 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | LITAF | Q99732 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4988592 | 0.98 | TDP1 (0.52) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL19456961 | 0.88 | TDP1 (0.54) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4984289 | 0.88 | TDP1 (0.51) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL241840 | 0.87 | TDP1 (0.62) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL241835 | 0.87 | TDP1 (0.53) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL241362 | 0.85 | TDP1 (0.57) | TDP1JAK2JAK1TYK2JAK3 | |
| Genz-644282 SCHEMBL29632787 | 0.85 | TDP1 (0.52) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29360706 | 0.85 | TDP1 (0.69) | TDP1JAK2JAK1TYK2JAK3 | |
| SCHEMBL241242 | 0.85 | TDP1 (0.69) | TDP1JAK2JAK1TYK2JAK3 | |
| Genz-644282 SCHEMBL241696 | 0.85 | TDP1 (0.52) | TDP1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453812-B1 | CYTOTOXIC AGENTS | UNIV RUTGERS (US) | 2008-08-20 | — | — | EP | disclosed |