Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.83 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017722 | 0.94 | CHEK1 (0.80) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4287873 | 0.92 | CHEK1 (0.79) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL13659635 | 0.91 | CHEK1 (0.84) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4293965 | 0.91 | CHEK1 (1.00) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4292384 | 0.90 | CHEK1 (0.82) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4287654 | 0.89 | CHEK1 (0.79) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4292566 | 0.88 | CHEK1 (0.71) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4287256 | 0.88 | CHEK1 (0.78) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4289999 | 0.86 | CHEK1 (0.75) | CHEK1NPC1RAB9AATMHRH3 | |
| SCHEMBL4287406 | 0.85 | CHEK1 (0.68) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | claimed |
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |