Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3630896 | 0.83 | MCL1 (0.33) | MCL1BCL2L1NPSR1PPARGRXFP1 | |
| SCHEMBL9182662 | 0.83 | BCL2L1 (0.51) | MCL1BCL2L1RAB9ANPC1MAPT | |
| SCHEMBL18869229 | 0.76 | MCL1 (0.59) | MCL1BCL2L1RAB9ANPC1MAPT | |
| SCHEMBL5394529 | 0.74 | MCL1 (0.50) | MCL1RAB9ANPC1MAPTLMNA | |
| SCHEMBL5017261 | 0.72 | BCL2L1 (0.55) | MCL1BCL2L1RAB9ANPC1MAPT | |
| SCHEMBL7397524 | 0.72 | STING1 (0.48) | MAPTLMNAGAASMN1; SMN2NPSR1 | |
| SCHEMBL415459 | 0.71 | MCL1 (0.77) | MCL1BCL2L1RAB9ANPC1MAPT | |
| SCHEMBL5023231 | 0.71 | MCL1 (0.77) | MCL1BCL2L1RAB9ANPC1MAPT | |
| SCHEMBL417349 | 0.71 | MCL1 (1.00) | MCL1BCL2L1RAB9ANPC1MAPT | |
| SCHEMBL18858484 | 0.70 | MCL1 (0.53) | MCL1BCL2L1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1915369-A1 | NOVEL SUBSTITUTED 1,2,3-T II AZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTIIENE BIOSYNTHESIS INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-30 | — | — | EP | disclosed |
| WO-2007016784-A1 | NOVEL SUBSTITUTED 1,2,3-TΠAZOLYLMETHYL-BENZOTHIOPHENE OR -INDOLE AND THEIR USE AS LEUKOTΠENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-02-15 | — | — | WO | disclosed |