Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.71 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA7 | P43166 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024875 | 0.90 | TRPV1 (0.59) | TRPV1KDRCA1CA2CA7 | |
| SCHEMBL5015914 | 0.86 | TRPV1 (0.59) | TRPV1KDRCA1CA2CA7 | |
| SCHEMBL5130375 | 0.84 | TRPV1 (0.60) | TRPV1KDRCA1CA2CA7 | |
| SCHEMBL5022536 | 0.84 | TRPV1 (0.53) | TRPV1KDRCA1CA2CA7 | |
| SCHEMBL5123803 | 0.83 | TRPV1 (0.85) | TRPV1KDR | |
| SCHEMBL4332089 | 0.83 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL4335739 | 0.83 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL4343306 | 0.83 | TRPV1 (1.00) | TRPV1KDR | |
| SCHEMBL5115369 | 0.81 | TRPV1 (0.70) | TRPV1KDRRAF1BRAF | |
| SCHEMBL5118697 | 0.81 | TRPV1 (0.76) | TRPV1KDRCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687262-B1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | BAYER HEALTHCARE AG (DE) | 2008-11-19 | — | — | EP | claimed |
| US-20080058377-A1 | Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators | BAYER HEALTHCARE AG (DE) | 2008-03-06 | — | — | US | claimed |
| EP-1687262-B1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | BAYER HEALTHCARE AG (DE) | 2008-11-19 | — | — | EP | disclosed |
| EP-1687262-B1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | BAYER HEALTHCARE AG (DE) | 2008-11-19 | — | — | EP | disclosed |
| US-20080058377-A1 | Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators | BAYER HEALTHCARE AG (DE) | 2008-03-06 | — | — | US | disclosed |
| US-20080058377-A1 | Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators | BAYER HEALTHCARE AG (DE) | 2008-03-06 | — | — | US | disclosed |
| US-20080058377-A1 | Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators | BAYER HEALTHCARE AG (DE) | 2008-03-06 | — | — | US | disclosed |
| EP-1687262-A1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | Bayer HealthCare AG (DE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005044786-A1 | BICYCLIC AMIDE, CARBAMATE OR UREA DERIVATIVES AS VANILLOID RECEPTOR MODULATORS | BAYER HEALTHCARE AG (DE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058377-A1 | Bicyclic Amide, Carbamate or Urea Derivatives as Vanilloid Receptor Modulators | NMUR1, CNR1, AVPR1A | TRPV1 7/4885KDR 958/4885CA1 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.