Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287314 | 0.84 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4300689 | 0.84 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4291840 | 0.83 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4297132 | 0.83 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4291988 | 0.81 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4290133 | 0.81 | CHEK1 (0.79) | CHEK1 | |
| SCHEMBL4292485 | 0.81 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4287553 | 0.81 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL4289226 | 0.80 | CHEK1 (0.67) | CHEK1 | |
| SCHEMBL4294664 | 0.80 | CHEK1 (0.78) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |