Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28398203 | 0.84 | USP2 (0.41) | USP2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL4397835 | 0.82 | USP2 (0.40) | USP2TSHRITGB3ITGA2BHTT | |
| SCHEMBL4397844 | 0.82 | USP2 (0.40) | USP2TSHRITGB3ITGA2BHTT | |
| SCHEMBL29182379 | 0.77 | TSHR (0.37) | USP2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29182377 | 0.77 | TSHR (0.37) | USP2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9494373 | 0.76 | USP2 (0.72) | USP2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5172119 | 0.76 | USP2 (0.72) | USP2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29182394 | 0.76 | TSHR (0.36) | USP2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29182393 | 0.76 | TSHR (0.36) | USP2PSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL5171901 | 0.76 | USP2 (0.71) | USP2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524936-B2 | Manufacturing process for sitagliptin from L-aspartic acid | SOUKUP MILAN (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524936-B2 | Manufacturing process for sitagliptin from L-aspartic acid | SOUKUP MILAN (US) | 2013-09-03 | — | — | US | disclosed |
| US-20120123144-A1 | Manufacturing process for sitagliptin from L-aspartic acid | Drug Process Licensing Associates, LLC (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120123144-A1 | Manufacturing process for sitagliptin from L-aspartic acid | Drug Process Licensing Associates, LLC (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123144-A1 | Manufacturing process for sitagliptin from L-aspartic acid | DPP4, DPP9, DPP7 | USP2 3427/4885PSEN1 1509/4885PSEN2 1878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.