Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | TTK | P33981 | 4/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4569488 | 0.82 | PIK3CG (0.39) | EGFRERBB2ERBB4IRAK1IRAK4 | |
| SCHEMBL14649370 | 0.79 | PIK3CG (0.54) | EGFRERBB2ERBB4IRAK1IRAK4 | |
| SCHEMBL4569401 | 0.79 | PIK3CG (0.37) | EGFRERBB2ERBB4IRAK1IRAK4 | |
| SCHEMBL4569410 | 0.79 | IRAK4 (0.41) | EGFRERBB2ERBB4IRAK1IRAK4 | |
| SCHEMBL4569435 | 0.78 | PIK3CG (0.39) | EGFRERBB2ERBB4PIK3CDPIK3R2 | |
| SCHEMBL4569411 | 0.78 | PIK3CG (0.39) | EGFRERBB2ERBB4IRAK1IRAK4 | |
| SCHEMBL14649241 | 0.77 | PIK3CG (0.64) | EGFRERBB2ERBB4PIK3CDPIK3R2 | |
| SCHEMBL14649174 | 0.77 | PIK3CG (0.64) | PIK3CDPIK3R2PIK3CGPDE3A | |
| SCHEMBL4569447 | 0.77 | PIK3CG (0.44) | EGFRERBB2ERBB4IRAK4PIK3CD | |
| SCHEMBL14667235 | 0.74 | PIK3CG (0.59) | PIK3CDPIK3R2PIK3CGPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064973-A2 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |