Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC3 | Q13489 | 15/20 | 0.46 |
| ▸ | XIAP | P98170 | 12/20 | 0.46 |
| ▸ | BIRC2 | Q13490 | 2/20 | 0.46 |
| ▸ | BIRC7 | Q96CA5 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 10/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12944780 | 0.91 | BIRC3 (0.55) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL17277661 | 0.91 | BIRC3 (0.55) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL949964 | 0.91 | BIRC3 (0.55) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL12914213 | 0.91 | BIRC3 (0.55) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL5019948 | 0.91 | BIRC3 (0.55) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL12944751 | 0.89 | BIRC3 (0.54) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL19054948 | 0.88 | BIRC3 (0.52) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL12914214 | 0.84 | BIRC3 (0.48) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL5019961 | 0.80 | XIAP (0.37) | BIRC3XIAPBIRC2BIRC7 | |
| SCHEMBL25461010 | 0.75 | BIRC3 (0.60) | BIRC3XIAPBIRC2BIRC7TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073579-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20130012564-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8283372-B2 | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2012-10-09 | — | — | US | disclosed |
| US-20120115922-A1 | SMAC MIMETEC | MEDIVIR AB (SE) | 2012-05-10 | — | — | US | disclosed |
| US-20110003877-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012564-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20110003877-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20120115922-A1 | SMAC MIMETEC | SMARCC1, SMARCC2, SMARCE1 | BIRC3 30/4885XIAP 60/4885BIRC2 15/4885 |
| US-20140073579-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.