Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.54 |
| ▸ | IL1RN | P18510 | 1/20 | 0.54 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397674 | 0.91 | HDAC1 (0.78) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL397675 | 0.91 | HDAC1 (0.78) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5020609 | 0.87 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL396739 | 0.85 | HDAC1 (0.69) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL396738 | 0.85 | HDAC1 (0.69) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6242252 | 0.83 | HDAC1 (0.79) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6242242 | 0.83 | HDAC1 (0.79) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL397356 | 0.80 | HDAC1 (0.62) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL397355 | 0.80 | HDAC1 (0.62) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL396810 | 0.78 | SMN1; SMN2 (0.62) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43343-E1 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-05-01 | — | — | US | disclosed |