Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 9/20 | 0.48 |
| ▸ | JAK2 | O60674 | 8/20 | 0.48 |
| ▸ | JAK1 | P23458 | 6/20 | 0.48 |
| ▸ | TYK2 | P29597 | 5/20 | 0.48 |
| ▸ | STAT3 | P40763 | 4/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561735 | 0.89 | JAK2 (0.44) | IGF1RJAK3JAK2JAK1TYK2 | |
| SCHEMBL4560086 | 0.88 | JAK2 (0.47) | JAK3JAK2JAK1TYK2STAT3 | |
| SCHEMBL4561036 | 0.87 | JAK3 (0.46) | IGF1RJAK3JAK2JAK1TYK2 | |
| SCHEMBL4559900 | 0.87 | JAK3 (0.45) | IGF1RJAK3JAK2JAK1TYK2 | |
| SCHEMBL4561602 | 0.86 | JAK3 (0.45) | IGF1RJAK3JAK2JAK1TYK2 | |
| SCHEMBL4561814 | 0.85 | LRRK2 (0.47) | IGF1RJAK3JAK2JAK1TYK2 | |
| SCHEMBL4561798 | 0.85 | JAK1 (0.52) | IGF1RJAK3JAK2JAK1TYK2 | |
| SCHEMBL29754155 | 0.85 | JAK1 (0.52) | IGF1RJAK3JAK2JAK1TYK2 | |
| SCHEMBL4561973 | 0.85 | JAK2 (0.44) | JAK3JAK2JAK1TYK2STAT3 | |
| SCHEMBL4561704 | 0.82 | JAK2 (0.49) | JAK3JAK2JAK1TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |