Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.53 |
| ▸ | JAK1 | P23458 | 5/20 | 0.53 |
| ▸ | JAK3 | P52333 | 3/20 | 0.53 |
| ▸ | TYK2 | P29597 | 3/20 | 0.53 |
| ▸ | STAT3 | P40763 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 4/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561964 | 0.89 | JAK2 (0.55) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL4559525 | 0.86 | JAK2 (0.54) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL4559534 | 0.86 | JAK2 (0.52) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL4561907 | 0.84 | JAK2 (0.52) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL4562444 | 0.84 | JAK2 (0.52) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL4543457 | 0.84 | JAK2 (0.50) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL4562769 | 0.83 | JAK2 (0.49) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL22097741 | 0.83 | JAK2 (0.54) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL29754252 | 0.82 | JAK1 (0.58) | JAK2JAK1JAK3TYK2STAT3 | |
| SCHEMBL22545979 | 0.82 | JAK1 (0.58) | JAK2JAK1JAK3TYK2STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062704-A1 | PYRIDINE COMPOUNDS AND AZA ANALOGUES THEREOF AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |