Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283204 | 0.85 | NPC1 (0.68) | NPC1MKNK1EGFRERBB3MEN1 | |
| Hydrochloric Acid SCHEMBL2176150 | 0.84 | NPC1 (0.66) | NPC1MKNK1EGFRERBB3MEN1 | |
| SCHEMBL5674223 | 0.82 | NPC1 (0.64) | NPC1MKNK1EGFRERBB3MEN1 | |
| SCHEMBL22328022 | 0.82 | NPC1 (0.64) | NPC1MKNK1EGFRERBB3MEN1 | |
| SCHEMBL4663995 | 0.82 | NPC1 (0.64) | NPC1MKNK1EGFRERBB3MEN1 | |
| SCHEMBL28805101 | 0.82 | NPC1 (0.69) | NPC1MKNK1EGFRERBB3MEN1 | |
| SCHEMBL12487147 | 0.82 | NPC1 (0.64) | NPC1MKNK1EGFRERBB3MEN1 | |
| SCHEMBL857502 | 0.81 | NPC1 (0.63) | NPC1MKNK1EGFRERBB3MEN1 | |
| SCHEMBL691533 | 0.81 | EGFR (0.57) | NPC1EGFRERBB3 | |
| Hydrochloric Acid SCHEMBL2176643 | 0.80 | NPC1 (0.61) | NPC1MKNK1EGFRERBB3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101438288-A | Regulation of phosphoryl transferase activity of glutamine synthetase | CSIR CORP (ZA) | 2009-05-20 | — | — | CN | disclosed |
| EP-2008210-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |
| EP-1107958-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-08-16 | — | — | EP | disclosed |
| US-6632820-B1 | Anticancer agents | ASTRAZENECA AB (SE) | 2003-10-14 | — | — | US | disclosed |
| EP-1107958-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012486-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |