Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024110 | 0.85 | KDM4E (0.34) | KDM4EHPGDNPSR1PDE3BPDE3A | |
| SCHEMBL4292026 | 0.68 | KDM4E (0.42) | KDM4EHPGDNPSR1PLA2G2ANR4A2 | |
| SCHEMBL5024275 | 0.68 | LIMK1 (0.41) | KDM4EHPGD | |
| SCHEMBL522217 | 0.68 | GAA (0.46) | KDM4EHPGDNPSR1PDE3BPDE3A | |
| SCHEMBL15543978 | 0.67 | GAA (0.43) | KDM4EHPGDNR4A2GAA | |
| SCHEMBL4297736 | 0.67 | CHEK1 (0.67) | KDM4EPDE3BPDE3ANR4A2 | |
| SCHEMBL5017561 | 0.66 | BCHE (0.37) | KDM4EHPGDNR4A2 | |
| SCHEMBL5015727 | 0.66 | DPP4 (0.50) | KDM4E | |
| SCHEMBL14626469 | 0.66 | GSK3B (0.38) | KDM4EHPGDPLA2G2ACDK4CCND1 | |
| SCHEMBL4293070 | 0.64 | KDM4E (0.38) | KDM4EHPGDNPSR1PLA2G2ACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | claimed |
| EP-1904449-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008502-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-01-18 | — | — | WO | disclosed |