Sugi Predict

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SCHEMBL5025920

SCHEMBL5025920

Cc1ccc(C(=O)Nc2ccc(F)cc2)cc1Nc1nc(-c2cccnc2)cs1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 12/20 0.67
▸ BCR P11274 11/20 0.67
▸ PDGFRB P09619 3/20 0.67
▸ HDAC3 O15379 2/20 0.67
▸ KDR P35968 2/20 0.67
▸ HDAC4 P56524 2/20 0.67
▸ HDAC1 Q13547 2/20 0.67
▸ HDAC7 Q8WUI4 2/20 0.67
▸ HDAC2 Q92769 2/20 0.67
▸ HDAC10 Q969S8 2/20 0.67
▸ HDAC11 Q96DB2 2/20 0.67
▸ HDAC8 Q9BY41 2/20 0.67
▸ HDAC6 Q9UBN7 2/20 0.67
▸ HDAC9 Q9UKV0 2/20 0.67
▸ HDAC5 Q9UQL6 2/20 0.67
▸ KIT P10721 2/20 0.64
▸ EGFR P00533 1/20 0.64
▸ ERBB2 P04626 1/20 0.64
▸ LCK P06239 1/20 0.64
▸ FYN P06241 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL716396 0.94 ABL1 (0.75) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL718498 0.93 ABL1 (0.70) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL5025230 0.91 ROCK1 (0.59) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL14286289 0.90 ABL1 (0.71) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL716826 0.89 ABL1 (0.68) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL5029337 0.89 GAA (0.61) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL717030 0.89 GAA (0.65) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL5025940 0.89 ABL1 (0.64) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL4905534 0.88 ABL1 (0.67) ABL1BCRPDGFRBHDAC3KDR
SCHEMBL5027553 0.88 ABL1 (0.70) ABL1BCRPDGFRBHDAC3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1934107-A 2- (3-substituted aryl) amino-4-aryl-thiazoles as tyrosine kinase inhibitors AB SCIENCE (FR) 2007-03-21 — — CN claimed
EP-1711497-A1 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS AB Science (FR) 2006-10-18 — — EP claimed
WO-2005073225-A1 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS AB SCIENCE (FR) 2005-08-11 — — WO claimed
US-20080039466-A1 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors AB SCIENCE 2008-02-14 — — US disclosed
US-20080039466-A1 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors AB SCIENCE 2008-02-14 — — US disclosed
CN-1934107-A 2- (3-substituted aryl) amino-4-aryl-thiazoles as tyrosine kinase inhibitors AB SCIENCE (FR) 2007-03-21 — — CN disclosed
EP-1711497-A1 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS AB Science (FR) 2006-10-18 — — EP disclosed
WO-2005073225-A1 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS AB SCIENCE (FR) 2005-08-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080039466-A1 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors KIT, MAP3K2, RET ABL1 22/4885BCR 349/4885PDGFRB 60/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.