Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | HRH2 | P25021 | 9/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11363387 | 0.98 | CYP1A2 (0.53) | CYP1A2HRH2HRH4HRH1ALDH1A1 | |
| SCHEMBL4636871 | 0.85 | HRH2 (0.53) | CYP1A2HRH2HRH4HRH1ALDH1A1 | |
| SCHEMBL999649 | 0.81 | HRH2 (0.59) | CYP1A2HRH2HRH4HRH1ALDH1A1 | |
| Bicarbonate SCHEMBL27848196 | 0.81 | HRH2 (0.53) | CYP1A2HRH2HRH4HRH1ALDH1A1 | |
| SCHEMBL1540434 | 0.80 | HTT (0.51) | CYP1A2HRH2HRH4HRH1ALDH1A1 | |
| SCHEMBL873381 | 0.80 | PTGDR2 (0.53) | CYP1A2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL11157086 | 0.79 | SMN1; SMN2 (0.53) | CYP1A2HRH2HRH4HRH1ALDH1A1 | |
| SCHEMBL15740329 | 0.78 | CYP1A2 (0.56) | CYP1A2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL27734024 | 0.78 | CYP1A2 (0.51) | CYP1A2HRH2HRH4HRH1ALDH1A1 | |
| SCHEMBL27719752 | 0.78 | CYP1A2 (0.51) | CYP1A2HRH2HRH4HRH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299381-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-07 | — | — | EP | disclosed |
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
| US-20060046987-A1 | Substituted quinazoline derivatives and their use as inhibitors | ASTRAZENECA AB (SE) | 2006-03-02 | — | — | US | disclosed |
| US-20030187002-A1 | Substituted quinazoline derivatives and their use as inhibitors | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | US | disclosed |
| EP-1299381-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000649-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |
| US-4363909-A | ANTIVIRAL AGENTS | RHONE POULENC INDUSTRIES (FR) | 1982-12-14 | — | — | US | disclosed |
| US-4254260-A | 3-Substituted-7-substituted alkanamido-3-cephem-4-carboxylic acid compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060046987-A1 | Substituted quinazoline derivatives and their use as inhibitors | AURKA, AURKB, AURKC | CYP1A2 2362/4885HRH2 1151/4885HRH4 700/4885 |
| US-20030187002-A1 | Substituted quinazoline derivatives and their use as inhibitors | AURKA, AURKC, AURKB | CYP1A2 1768/4885HRH2 1128/4885HRH4 694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.