Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | BCL6 | P41182 | 3/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654088 | 0.83 | SYK (0.74) | SYKAURKABCL6NCOR2 | |
| SCHEMBL4001465 | 0.81 | SYK (0.75) | SYKAURKACDK4 | |
| SCHEMBL5025941 | 0.81 | SYK (0.51) | SYKAURKAEGFR | |
| SCHEMBL5026161 | 0.79 | SYK (0.58) | SYKAURKACDK4EGFR | |
| SCHEMBL655280 | 0.77 | SYK (0.73) | SYKAURKABCL6 | |
| SCHEMBL19313055 | 0.77 | SYK (0.72) | SYKAURKABCL6 | |
| SCHEMBL5138413 | 0.76 | SYK (0.56) | SYKAURKAEGFR | |
| SCHEMBL4002656 | 0.76 | SYK (0.51) | SYKAURKAEGFR | |
| SCHEMBL5025911 | 0.76 | SYK (0.64) | SYKAURKAEGFR | |
| SCHEMBL29557252 | 0.75 | SYK (0.56) | SYKAURKABCL6CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | disclosed |