Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.53 |
| ▸ | SYK | P43405 | 8/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | CDK1 | P06493 | 5/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.53 |
| ▸ | CDC7 | O00311 | 2/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PAK4 | O96013 | 2/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3997856 | 0.91 | SYK (0.62) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL5025433 | 0.91 | CDK2 (0.51) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL5025463 | 0.88 | SYK (0.59) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL5025579 | 0.87 | SYK (0.68) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL5025512 | 0.86 | SYK (0.59) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL4002841 | 0.85 | JAK3 (0.55) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL4000186 | 0.85 | JAK3 (0.52) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL4002793 | 0.84 | JAK3 (0.64) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL3999425 | 0.84 | SYK (0.68) | JAK3SYKCDK2CDK1CDK5 | |
| SCHEMBL5023858 | 0.83 | EGFR (0.51) | JAK3SYKCDK2CDK1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | claimed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | claimed |
| EP-1904457-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Rigel Pharmaceuticals, Inc. (US) | 2008-04-02 | — | — | EP | disclosed |
| WO-2006133426-A2 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-14 | — | — | WO | disclosed |