⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5334280 | 0.69 | CETP (0.35) | — | |
| SCHEMBL18418234 | 0.69 | — | — | |
| SCHEMBL9451446 | 0.69 | — | — | |
| SCHEMBL19551250 | 0.68 | — | — | |
| SCHEMBL3697794 | 0.68 | — | — | |
| SCHEMBL165046 | 0.68 | — | — | |
| SCHEMBL7677321 | 0.68 | — | — | |
| SCHEMBL22399 | 0.67 | — | — | |
| SCHEMBL27954089 | 0.67 | — | — | |
| SCHEMBL24051166 | 0.65 | TDP1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006127024-A1 | REAGENTS AND METHODS FOR LABELING TERMINAL OLEFINS | EISAI CO. LTD. (JP) | 2006-11-30 | — | — | WO | claimed |
| US-20060045846-A1 | Reagents and methods for labeling terminal olefins | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-03-02 | — | — | US | claimed |
| EP-2949652-B1 | Intermediates for the preparation of halichondrin B | EISAI R&D MAN CO LTD (JP) | 2019-08-07 | — | — | EP | disclosed |
| EP-2686441-B1 | METHODS AND USES FOR PREDICTING RESPONSE TO ERIBULIN | EISAI R&D MAN CO LTD (JP) | 2019-05-08 | — | — | EP | disclosed |
| US-RE46965-E1 | Intermediates for the preparation of analogs of Halichondrin B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-07-24 | — | — | US | disclosed |
| US-9637795-B2 | Methods and compositions for predicting response to eribulin | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-05-02 | — | — | US | disclosed |
| CN-101899026-B | Intermediates for the preparation of analogs of halichondrin B | 卫材R&D管理有限公司 | 2016-08-03 | — | — | CN | disclosed |
| US-9303050-B2 | Intermediates for the preparation of analogs of Halichondrin B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-04-05 | — | — | US | disclosed |
| EP-2949652-A1 | Intermediates for the preparation of halichondrin B | Eisai R&D Management Co., Ltd. (JP) | 2015-12-02 | — | — | EP | disclosed |
| CN-104876896-A | Intermediates for the preparation of analogs of halichondrin B | EISAI R&D MAN CO LTD | 2015-09-02 | — | — | CN | disclosed |
| US-20150232490-A1 | INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-08-20 | — | — | US | disclosed |
| EP-1653953-A2 | DRUG DELIVERY METHODS AND DEVICES | Eisai Co., Ltd. (JP) | 2006-05-10 | — | — | EP | disclosed |
| US-20060045846-A1 | Reagents and methods for labeling terminal olefins | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-03-02 | — | — | US | disclosed |
| WO-2005118565-A1 | INTERMEDIATES FOR THE PREPARATION OF HALICHONDRIN B | EISAI CO., LTD. (JP) | 2005-12-15 | — | — | WO | disclosed |
| WO-2005011589-A2 | DRUG DELIVERY METHODS AND DEVICES | EISAI CO., LTD. (JP) | 2005-02-10 | — | — | WO | disclosed |
| EP-1087960-A4 | MACROCYCLIC ANALOGS AND METHODS OF THEIR USE AND PREPARATION | EISAI CO LTD (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6365759-B1 | ANTICARCINOGENIC AND ANTIMITOTIC AGENTS; STABLE; MELANOMA; LEUKEMIA; COLON; MAMMARY GLANDS; OVARIES; PROSTATE GLANDS; LUNGS | EISAI CO., LTD. (JP) | 2002-04-02 | — | — | US | disclosed |
| US-6214865-B1 | Macrocyclic analogs and methods of their use and preparation | EISAI CO., LTD. (JP) | 2001-04-10 | — | — | US | disclosed |
| EP-1087960-A1 | MACROCYCLIC ANALOGS AND METHODS OF THEIR USE AND PREPARATION | EISAI CO., LTD. (JP) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065894-A1 | MACROCYCLIC ANALOGS AND METHODS OF THEIR USE AND PREPARATION | EISAI CO., LTD. (JP) | 1999-12-23 | — | — | WO | disclosed |