Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | FGR | P09769 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.57 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.57 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9236313 | 1.00 | SYK (0.58) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL2715579 | 0.90 | SYK (0.58) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL5028032 | 0.89 | SYK (0.58) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL5028025 | 0.88 | SYK (0.76) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL14929575 | 0.88 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL9110112 | 0.88 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL14908938 | 0.88 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL14977597 | 0.86 | SYK (0.77) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL1354115 | 0.86 | SYK (0.77) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL5027996 | 0.86 | SYK (0.74) | SYKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |