⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21328 | 0.95 | — | — | |
| SCHEMBL11684950 | 0.91 | — | — | |
| SCHEMBL16949817 | 0.91 | — | — | |
| SCHEMBL59922 | 0.91 | — | — | |
| SCHEMBL17353509 | 0.91 | — | — | |
| SCHEMBL9079875 | 0.91 | — | — | |
| SCHEMBL1119613 | 0.91 | — | — | |
| SCHEMBL36486 | 0.91 | — | — | |
| SCHEMBL105478 | 0.91 | — | — | |
| SCHEMBL3753676 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3311843-A1 | COMPOSITIONS COMPRISING DITHIOCARBAMATE AND CYCLODEXTRIN | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts (DE) | 2018-04-25 | — | — | EP | claimed |
| US-20070232692-A1 | Method of Treating Cancer Using Dithiocarbamate Derivatives | THE UNIVERSITY OF UTAH | 2007-10-04 | — | — | US | claimed |
| EP-3311843-A1 | COMPOSITIONS COMPRISING DITHIOCARBAMATE AND CYCLODEXTRIN | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts (DE) | 2018-04-25 | — | — | EP | disclosed |
| US-20140220152-A1 | Compositions and Methods for Detecting, Treating, or Preventing Reductive Stress | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2014-08-07 | — | — | US | disclosed |
| US-20120030779-A1 | COMPOSITIONS AND METHODS FOR DETECTING, TREATING, OR PREVENTING REDUCTIVE STRESS | UNIVERSITY OF UTAH RESEARCH FOUNDTION (UT) | 2012-02-02 | — | — | US | disclosed |
| US-20110206756-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2011-08-25 | — | — | US | disclosed |
| CN-102026625-A | Dithiocarbamate metal chelates and methods of making and using thereof | UNIV UTAH RES FOUND | 2011-04-20 | — | — | CN | disclosed |
| EP-2265256-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | University of Utah Research Foundation (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009117333-A1 | DITHIOCARBAMATE METAL CHELATES AND METHODS OF MAKING AND USING THEREOF | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2009-09-24 | — | — | WO | disclosed |
| EP-2101567-A2 | COMPOSITIONS AND METHODS FOR DETECTING, TREATING, OR PREVENTING REDUCTIVE STRESS | University of Utah Research Foundation (US) | 2009-09-23 | — | — | EP | disclosed |
| EP-1328267-B1 | METHOD OF TREATING CANCER USING DITHIOCARBAMATE DERIVATIVES | UNIV UTAH (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2006023714-A2 | DITHIOCARBAMATE DERIVATIVES AND THEIR USE FOR TREATING CANCER | AAIPHARMA INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20050096304-A1 | Method of treating cancer using dithiocarbamate derivatives | WATER STREET HEALTHCARE PARTNERS II L.P. | 2005-05-05 | — | — | US | disclosed |
| US-20040171678-A1 | Method of treating cancer using dithiocarbamate derivatives | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS MEDICAL CENTER | 2004-09-02 | — | — | US | disclosed |
| US-6706759-B1 | SENSITIZING TUMORS TO CONVENTIONAL CANCER CHEMOTHERAPY BY BLOCKING THE P-GLYCOPROTEIN MEMBRANE TOXIN EXTRUSION PUMP AND FOR SENSITIZING AIDS PATIENTS TO ANTI-RETROVIRAL THERAPY BY BLOCKING THE P-GLYCOPROTEIN MEMBRANE TOXIN EXTRUSION PUMP | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY | 2004-03-16 | — | — | US | disclosed |
| US-20030229064-A1 | Method of treating cancer using dithiocarbamate derivatives | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS MEDICAL CENTER | 2003-12-11 | — | — | US | disclosed |
| EP-1328267-A2 | METHOD OF TREATING CANCER USING DITHIOCARBAMATE DERIVATIVES | Charlotte-Mecklenburg Hospital Authority doing business as Carolinas Medical Center (US) | 2003-07-23 | — | — | EP | disclosed |
| US-6548540-B2 | Administering dithiocarbamate thiolate anions to sensitize humans to conventional chemotherapy by blocking the p-glycoprotein membrane toxin extrusion pump | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY | 2003-04-15 | — | — | US | disclosed |
| WO-2002028349-A2 | METHOD OF TREATING CANCER USING DITHIOCARBAMATE DERIVATIVES | CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY, DOING BUSINESS AS CAROLINAS MEDICAL CENTER (US) | 2002-04-11 | — | — | WO | disclosed |
| US-20010016600-A1 | Method of treating cancer using dithiocarbamate derivatives | THE UNIVERSITY OF UTAH | 2001-08-23 | — | — | US | disclosed |