Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.48 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714865 | 0.90 | SYK (0.61) | SYKKCNH2JAK2FLT3ROCK2 | |
| SCHEMBL18926035 | 0.88 | SYK (0.56) | SYKKCNH2JAK2FLT3ROCK2 | |
| SCHEMBL2717181 | 0.83 | SYK (0.79) | SYKKCNH2JAK2FLT3ROCK2 | |
| SCHEMBL18925464 | 0.83 | SYK (0.66) | SYKKCNH2JAK2FLT3ROCK2 | |
| SCHEMBL5027691 | 0.82 | SYK (0.66) | SYKKCNH2JAK2FLT3ROCK2 | |
| SCHEMBL5028025 | 0.80 | SYK (0.76) | SYKKCNH2JAK2FLT3ROCK2 | |
| SCHEMBL2715579 | 0.79 | SYK (0.58) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL2727887 | 0.78 | SYK (0.78) | SYKKCNH2JAK2FLT3ROCK2 | |
| SCHEMBL20750871 | 0.77 | SYK (0.54) | SYKKCNH2JAK2FLT3FER | |
| SCHEMBL20750820 | 0.77 | SYK (0.54) | SYKKCNH2JAK2FLT3FER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |