Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 12/20 | 0.46 |
| ▸ | FER | P16591 | 6/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103815 | 0.89 | SYK (0.57) | SYKFERJAK2JAK1MAPK3 | |
| SCHEMBL18925343 | 0.87 | SYK (0.49) | SYKFERJAK2JAK1MAPK3 | |
| SCHEMBL20750756 | 0.85 | SYK (0.49) | SYKFERJAK2JAK1MAPK3 | |
| SCHEMBL9110458 | 0.84 | SYK (0.46) | SYKFERJAK2JAK1MAPK3 | |
| SCHEMBL9109865 | 0.82 | SYK (0.60) | SYKFERJAK2MAPK3MAPK1 | |
| SCHEMBL20750718 | 0.82 | SYK (0.49) | SYKFERJAK2JAK1MAPK3 | |
| SCHEMBL14910002 | 0.82 | SYK (0.60) | SYKFERJAK2MAPK3MAPK1 | |
| SCHEMBL2715375 | 0.77 | SYK (0.56) | SYKFERJAK2JAK1MAPK3 | |
| SCHEMBL18925591 | 0.77 | SYK (0.56) | SYKFERJAK2JAK1MAPK3 | |
| SCHEMBL9109214 | 0.77 | SYK (0.53) | SYKFERJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |