Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.64 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | YES1 | P07947 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 1/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.49 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.49 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235482 | 0.90 | SYK (0.79) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL5027944 | 0.79 | SYK (0.68) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL9107507 | 0.79 | SYK (0.68) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL9106552 | 0.78 | SYK (1.00) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL9109344 | 0.77 | SYK (0.64) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL18926094 | 0.77 | SYK (0.64) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL14911480 | 0.75 | SYK (0.62) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL5026668 | 0.75 | SYK (0.62) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL5027894 | 0.73 | SYK (0.66) | SYKKCNH2JAK2FLT3LCK | |
| SCHEMBL18925786 | 0.73 | SYK (0.77) | SYKKCNH2JAK2FLT3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |