Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3707904 | 0.85 | CYP2C19 (0.53) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL2938022 | 0.83 | CYP2C19 (0.57) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL7848700 | 0.78 | GAA (0.46) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL12923292 | 0.76 | GAA (0.44) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL8264963 | 0.76 | CYP2C19 (0.50) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL10826905 | 0.76 | KMT2A (0.45) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL4577419 | 0.76 | GAA (0.44) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL28630400 | 0.76 | GAA (0.44) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL1299240 | 0.74 | KMT2A (0.44) | GAAMGAMSIMGAM2KMT2A | |
| SCHEMBL8266120 | 0.74 | KMT2A (0.44) | GAAMGAMSIMGAM2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |