Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.67 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | GBA1 | P04062 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28795275 | 0.84 | KDM4E (0.55) | GRM5SORT1RAB9AKMT2A | |
| SCHEMBL935048 | 0.84 | GRM5 (0.52) | GRM5RAB9A | |
| SCHEMBL7910110 | 0.83 | GRM5 (0.72) | GRM5SORT1MAPTGBA1RAB9A | |
| SCHEMBL27655254 | 0.82 | GRM5 (0.77) | GRM5MAPTRAB9AKMT2A | |
| SCHEMBL935137 | 0.82 | CNR2 (0.51) | GRM5RAB9AKMT2A | |
| SCHEMBL3864266 | 0.82 | GRM5 (0.66) | GRM5SORT1MAPTGBA1RAB9A | |
| SCHEMBL22739187 | 0.81 | FGFR4 (0.55) | GRM5RAB9AKMT2A | |
| SCHEMBL8163804 | 0.81 | GRM5 (1.00) | GRM5MAPT | |
| Bromide SCHEMBL5026600 | 0.80 | GRM5 (0.98) | GRM5MAPT | |
| SCHEMBL16382275 | 0.79 | CNR2 (0.46) | GRM5RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008092072-A2 | MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 AND USES THEREOF | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-07-31 | — | — | WO | disclosed |