Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 9/20 | 0.55 |
| ▸ | BCR | P11274 | 9/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5027660 | 0.92 | MAPT (0.62) | MEN1KMT2ARAB9ANPC1ABL1 | |
| SCHEMBL5025230 | 0.90 | ROCK1 (0.59) | MEN1KMT2ARAB9ANPC1ABL1 | |
| SCHEMBL5025231 | 0.89 | MEN1 (0.60) | MEN1KMT2ARAB9ANPC1ABL1 | |
| SCHEMBL5023715 | 0.89 | ABL1 (0.60) | MEN1KMT2ACYP1A2ABL1BCR | |
| SCHEMBL5025283 | 0.89 | MAPT (0.62) | MEN1KMT2ARAB9ANPC1ABL1 | |
| SCHEMBL5025047 | 0.89 | ABL1 (0.56) | RAB9ANPC1ABL1BCRPDGFRB | |
| SCHEMBL5023651 | 0.88 | POLB (0.68) | MEN1KMT2AABL1BCRKDR | |
| SCHEMBL5027669 | 0.88 | ABL1 (0.55) | MEN1KMT2AABL1BCRPDGFRB | |
| SCHEMBL5972220 | 0.88 | MEN1 (0.55) | MEN1KMT2ARAB9ANPC1CYP1A2 | |
| SCHEMBL5025243 | 0.88 | ABL1 (0.59) | MEN1KMT2ARAB9ANPC1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | claimed |
| CN-1934107-A | 2- (3-substituted aryl) amino-4-aryl-thiazoles as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2007-03-21 | — | — | CN | claimed |
| EP-1711497-A1 | 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS | AB Science (FR) | 2006-10-18 | — | — | EP | claimed |
| WO-2005073225-A1 | 2-(3-SUBSTITUTED-ARYL)AMINO-4-ARYL-THIAZOLES AS TYROSINE KINASE INHIBITORS | AB SCIENCE (FR) | 2005-08-11 | — | — | WO | claimed |
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | disclosed |
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | disclosed |
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | AB SCIENCE | 2008-02-14 | — | — | US | disclosed |
| CN-1934107-A | 2- (3-substituted aryl) amino-4-aryl-thiazoles as tyrosine kinase inhibitors | AB SCIENCE (FR) | 2007-03-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039466-A1 | 2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors | KIT, MAP3K2, RET | MEN1 3301/4885KMT2A 576/4885RAB9A 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.