Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Estriol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 6/20 | 1.00 |
| ▸ | ESR2 known ✓ | Q92731 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | SHBG | P04278 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | SERPINA6 | P08185 | 2/20 | 1.00 |
| ▸ | AR | P10275 | 2/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | SNCA | P37840 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 1.00 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | STS | P08842 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Estriol SCHEMBL12180048 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL14373308 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL4896486 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL7004654 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL223196 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL13123063 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL23743979 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Epiestriol SCHEMBL221084 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL223226 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 | |
| Estriol SCHEMBL8941750 | 1.00 | ESR1 (1.00) | ESR1ESR2LMNASHBGCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111398219-B | Method for sensing and measuring estradiol by adopting graphene multiple signal amplification SPR (surface plasmon resonance) | 军事科学院军事医学研究院环境医学与作业医学研究所 | 2023-03-03 | — | — | CN | disclosed |
| CN-113063954-A | Estrogen time-resolved fluorescence and color development double-signal test strip and preparation method and application thereof | 江南大学 | 2021-07-02 | — | — | CN | disclosed |
| CN-111398219-A | Method for sensing and measuring estradiol by adopting graphene multiple signal amplification SPR (surface plasmon resonance) | 军事科学院军事医学研究院环境医学与作业医学研究所 | 2020-07-10 | — | — | CN | disclosed |
| CN-110618225-A | Method for constructing database to detect hormone | 吉林出入境检验检疫局检验检疫技术中心 | 2019-12-27 | — | — | CN | disclosed |
| US-20190214145-A1 | Method and systems for creating and screening patient metabolite profile to diagnose current medical condition, diagnose current treatment state and recommend new treatment regimen | KUREK ITZHAK (US) | 2019-07-11 | — | — | US | disclosed |
| WO-2008039360-A9 | ULTRASOUND-INDUCED DESTRUCTION OF TRACE-LEVEL ESTROGEN HORMONES IN AQUEOUS SOLUTIONS | UNIV VILLANOVA (US) | 2008-07-10 | — | — | WO | disclosed |
| WO-2008039360-A2 | ULTRASOUND-INDUCED DESTRUCTION OF TRACE-LEVEL ESTROGEN HORMONES IN AQUEOUS SOLUTIONS | VILLANOVA UNIVERSITY (US) | 2008-04-03 | — | — | WO | disclosed |
| EP-1590668-A2 | SCREENINIG AND TREATMENT METHODS FOR PREVENTION OF PRETERM DELIVERY | ADEZA BIOMEDICAL CORPORATION (US) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004071427-A2 | SCREENING AND TREATMENT METHODS FOR PREVENTION OF PRETERM DELIVERY | ADEZA BIOMEDICAL CORPORATION (US) | 2004-08-26 | — | — | WO | disclosed |
| US-4454232-A | IMMONASSAY, SURFACTANTS | BIO-RAD LABORATORIES, INC. (US) | 1984-06-12 | — | — | US | disclosed |