Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032118 | 0.88 | MAP2K1 (0.36) | MAP2K1MAP2K2L3MBTL1 | |
| SCHEMBL5031302 | 0.83 | MAP2K1 (0.35) | MAP2K1MAP2K2MAPK1KCNH2SYK | |
| SCHEMBL14920264 | 0.80 | MAP2K2 (0.38) | MAP2K1MAP2K2MAPK1KCNH2 | |
| SCHEMBL13723742 | 0.80 | MAP2K2 (0.38) | MAP2K1MAP2K2MAPK1KCNH2 | |
| SCHEMBL5031293 | 0.79 | MAP2K1 (0.44) | MAP2K1MAP2K2MAPK1KCNH2 | |
| SCHEMBL5032106 | 0.79 | MAP2K1 (0.37) | MAP2K1MAP2K2L3MBTL1 | |
| SCHEMBL5028995 | 0.79 | MAP2K2 (0.39) | MAP2K1MAP2K2MAPK1KCNH2SMN1; SMN2 | |
| SCHEMBL5028992 | 0.78 | KCNH2 (0.37) | MAP2K1MAP2K2KCNH2CYP1A2 | |
| SCHEMBL5031226 | 0.75 | MAP2K1 (0.48) | MAP2K1MAP2K2 | |
| SCHEMBL5031197 | 0.75 | MAP2K1 (0.48) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922307-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2007044084-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-04-19 | — | — | WO | claimed |