SCHEMBL5032792

SCHEMBL5032792

N#Cc1ccc(F)cc1-c1ccccc1CC(c1cccnc1)c1cccnc1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 18/20 0.64
KCNH2 Q12809 9/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL884187 0.91 KCNA5 (0.67) KCNA5KCNH2
SCHEMBL885804 0.82 KCNA5 (0.74) KCNA5KCNH2
SCHEMBL2063808 0.80 KCNA5 (0.61) KCNA5KCNH2
SCHEMBL884372 0.80 KCNA5 (0.80) KCNA5KCNH2
SCHEMBL884665 0.79 KCNA5 (0.60) KCNA5KCNH2
SCHEMBL885221 0.78 KCNA5 (1.00) KCNA5KCNH2
SCHEMBL2062791 0.77 KCNA5 (0.74) KCNA5KCNH2
SCHEMBL2063360 0.77 KCNA5 (0.71) KCNA5KCNH2
SCHEMBL2062845 0.76 KCNA5 (0.57) KCNA5KCNH2
SCHEMBL2062737 0.76 KCNA5 (0.69) KCNA5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940406-A2 POTASSIUM CHANNEL INHIBITORS Merck and Co., Inc. (US) 2008-07-09 EP disclosed
WO-2007050348-A2 POTASSIUM CHANNEL INHIBITORS MERCK & CO., INC. (US) 2007-05-03 WO disclosed