⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249139 | 0.76 | — | — | |
| SCHEMBL6629186 | 0.74 | — | — | |
| Methane SCHEMBL6376219 | 0.74 | KDM4E (0.54) | — | |
| SCHEMBL17431328 | 0.74 | — | — | |
| SCHEMBL16437203 | 0.71 | KDM4E (0.52) | — | |
| SCHEMBL12806957 | 0.71 | KDM4E (0.42) | — | |
| SCHEMBL6834128 | 0.70 | — | — | |
| SCHEMBL10304906 | 0.70 | — | — | |
| SCHEMBL7923017 | 0.70 | — | — | |
| SCHEMBL220418 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1906958-A2 | PYRAZOLO[3,4-B]PYRIDIN-2-YL]-BENZOIC ACID DERIVATIVES AS HIV INTEGRASE INHIBITORS | Ambrilia Biopharma Inc. (CA) | 2008-04-09 | — | — | EP | claimed |
| WO-2007000043-A2 | PYRAZOLO[3,4-B]PYRIDIN-2-YL]-BENZOIC ACID DERIVATIVES AS HIV INTEGRASE INHIBITORS | AMBRILIA BIOPHARMA INC. (CA) | 2007-01-04 | — | — | WO | claimed |
| US-6777535-B1 | USEFUL FOR TREATING CONDITIONS WHICH ARISE OR ARE EXACERBATED BY ANGIOGENESIS | ABBOTT LABORATORIES | 2004-08-17 | — | — | US | claimed |
| US-6753408-B1 | DRUGS USED FOR THERAPY | ABBVIE INC. | 2004-06-22 | — | — | US | claimed |
| EP-1242455-A1 | N-ALKYLATED PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | Abbott Laboratories (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001038397-A1 | N-ALKYLATED PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY | ABBOTT LABORATORIES (US) | 2001-05-31 | — | — | WO | claimed |
| EP-1906958-A2 | PYRAZOLO[3,4-B]PYRIDIN-2-YL]-BENZOIC ACID DERIVATIVES AS HIV INTEGRASE INHIBITORS | Ambrilia Biopharma Inc. (CA) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007000043-A2 | PYRAZOLO[3,4-B]PYRIDIN-2-YL]-BENZOIC ACID DERIVATIVES AS HIV INTEGRASE INHIBITORS | AMBRILIA BIOPHARMA INC. (CA) | 2007-01-04 | — | — | WO | disclosed |