SCHEMBL5033901

SCHEMBL5033901

[CH2]c1ccnc(C(=O)N2CCC3(CCN(Cc4cccc5c4OC(C)(C)C5)CC3)CC2)c1

nearest known ligand 0.69

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 17/20 0.69
KCNH2 Q12809 17/20 0.69
CYP2D6 P10635 2/20 0.44
CYP3A4 P08684 2/20 0.43
CYP1A2 P05177 1/20 0.43
USP2 O75604 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5033902 0.90 CCR8 (0.70) CCR8KCNH2CYP2D6CYP3A4CYP1A2
SCHEMBL4237911 0.90 CCR8 (0.70) CCR8KCNH2CYP2D6CYP3A4CYP1A2
SCHEMBL4243566 0.90 CCR8 (0.77) CCR8KCNH2CYP2D6CYP3A4CYP1A2
SCHEMBL4239397 0.88 CCR8 (0.70) CCR8KCNH2CYP2D6CYP3A4CYP1A2
Trifluoroacetic Acid SCHEMBL4237131 0.85 CCR8 (0.70) CCR8KCNH2CYP2D6CYP3A4CYP1A2
SCHEMBL4237544 0.84 CCR8 (0.77) CCR8KCNH2CYP2D6CYP3A4
SCHEMBL4235221 0.84 CCR8 (0.70) CCR8KCNH2CYP2D6CYP3A4CYP1A2
SCHEMBL4235585 0.84 CCR8 (0.74) CCR8KCNH2CYP2D6CYP3A4
Trifluoroacetic Acid SCHEMBL4243056 0.84 CCR8 (0.64) CCR8KCNH2CYP2D6CYP3A4CYP1A2
SCHEMBL4237176 0.83 CCR8 (0.69) CCR8KCNH2CYP2D6CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1926730-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES AstraZeneca AB (SE) 2008-06-04 EP claimed
WO-2007030061-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES ASTRAZENECA AB (SE) 2007-03-15 WO claimed