SCHEMBL5034222

SCHEMBL5034222

CC(=O)Oc1ccccc1C(=O)N1CCC2(CCN(Cc3cccc4c3OC(C)(C)C4)CC2)CC1

nearest known ligand 0.61

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 10/20 0.61
KCNH2 Q12809 10/20 0.61
CHRM2 P08172 1/20 0.48
CHRM3 P20309 1/20 0.48
CYP2D6 P10635 9/20 0.48
TSHR P16473 1/20 0.48
ALDH1A1 P00352 2/20 0.47
USP2 O75604 1/20 0.46
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4234438 0.85 CCR8 (0.76) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4233164 0.85 CCR8 (0.64) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4237303 0.85 CCR8 (0.64) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL13805605 0.84 CCR8 (0.61) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4237485 0.84 CCR8 (0.61) CCR8KCNH2CYP2D6TSHRALDH1A1
SCHEMBL4241943 0.84 CCR8 (0.66) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4234755 0.83 CCR8 (0.62) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4241738 0.83 CCR8 (0.62) CCR8KCNH2CHRM2CHRM3CYP2D6
SCHEMBL4233179 0.82 CCR8 (0.61) CCR8KCNH2CHRM2CHRM3CYP2D6
Acetic Acid SCHEMBL4237179 0.82 CCR8 (0.59) CCR8KCNH2CHRM2CHRM3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1926730-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES AstraZeneca AB (SE) 2008-06-04 EP disclosed
WO-2007030061-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES ASTRAZENECA AB (SE) 2007-03-15 WO disclosed