Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 6/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032877 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| Bromide SCHEMBL5036774 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL5035286 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL5036732 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL20579804 | 0.69 | SMN1; SMN2 (0.78) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL7502575 | 0.69 | SMN1; SMN2 (0.78) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL5032811 | 0.68 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL7499292 | 0.68 | SMN1; SMN2 (0.76) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL17018450 | 0.67 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 | |
| SCHEMBL15631933 | 0.66 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPK1RAB9AHCRTR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0984969-B1 | FUSED DIHYDROPYRANS | NYCOMED GMBH (DE) | 2008-07-09 | — | — | EP | disclosed |
| US-6160119-A | Fused dihydropyrans | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2000-12-12 | — | — | US | disclosed |
| EP-0984969-A1 | FUSED DIHYDROPYRANS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054188-A1 | FUSED DIHYDROPYRANS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-12-03 | — | — | WO | disclosed |