Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 14/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885030 | 0.78 | KCNA5 (0.45) | KCNA5KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL884735 | 0.77 | KCNA5 (0.43) | KCNA5KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2063804 | 0.76 | KCNA5 (0.47) | KCNA5KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL884635 | 0.75 | KCNA5 (0.51) | KCNA5KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2063582 | 0.74 | KCNA5 (0.45) | KCNA5KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL884666 | 0.74 | KCNA5 (0.50) | KCNA5KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL884227 | 0.73 | KCNA5 (0.47) | KCNA5KCNH2CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL884433 | 0.73 | KCNA5 (0.46) | KCNA5KCNH2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL885762 | 0.72 | KCNA5 (0.43) | KCNA5KCNH2 | |
| SCHEMBL884734 | 0.72 | KCNA5 (0.48) | KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | disclosed |