Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1960702 | 1.00 | MEN1 (0.48) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL1960704 | 1.00 | MEN1 (0.48) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL1962297 | 0.88 | MEN1 (0.49) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL1963705 | 0.88 | MEN1 (0.49) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL1960545 | 0.87 | MAPT (0.48) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL1960547 | 0.87 | MAPT (0.48) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL14514531 | 0.87 | MEN1 (0.52) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL9833531 | 0.83 | MAPT (0.41) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL9833537 | 0.83 | MAPT (0.41) | MEN1KMT2AALOX12THRBALDH1A1 | |
| SCHEMBL9834091 | 0.79 | MAPT (0.60) | MEN1KMT2AALOX12THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966158-A1 | SUBSTITUTED CINNOLINE DERIVATIVES AS GABAA-RECEPTOR MODULATORS AND METHOD FOR THEIR SYNTHESIS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007073283-A1 | SUBSTITUTED CINNOLINE DERIVATIVES AS GABAA-RECEPTOR MODULATORS AND METHOD FOR THEIR SYNTHESIS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |