⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036869 | 0.75 | PDE3B (0.32) | — | |
| SCHEMBL5039713 | 0.74 | — | — | |
| SCHEMBL5039898 | 0.74 | KDR (0.36) | — | |
| SCHEMBL3183021 | 0.72 | NPC1 (0.40) | — | |
| SCHEMBL5044349 | 0.71 | TRPV1 (0.36) | — | |
| SCHEMBL5039915 | 0.70 | TTBK1 (0.35) | — | |
| SCHEMBL2607092 | 0.70 | SMN1; SMN2 (0.45) | — | |
| SCHEMBL19153136 | 0.69 | NPC1 (0.39) | — | |
| SCHEMBL5036206 | 0.69 | HDAC6 (0.40) | — | |
| SCHEMBL5039907 | 0.67 | CDK8 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662310-A | Preparation method and application of thiazole ring derivative | 尚会霞 | 2020-09-15 | — | — | CN | claimed |
| EP-2513071-B1 | THIAZOLEDERIVATES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2015-06-17 | — | — | EP | claimed |
| EP-1715840-B1 | KERATIN DYEING COMPOSITIONS CONTAINING BICYCLIC FUSED 5-5 HETEROAROMATIC DYES | PROCTER & GAMBLE (US) | 2008-12-03 | — | — | EP | claimed |
| US-7303590-B2 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2007-12-04 | — | — | US | claimed |
| US-20050193502-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER, GAMBLE COMPANY, THE | 2005-09-08 | — | — | US | claimed |
| CN-114746089-A | Thiazolecarboxamide compounds and their use for the treatment of mycobacterial infections | 结核病药物开发全球联盟公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111662310-A | Preparation method and application of thiazole ring derivative | 尚会霞 | 2020-09-15 | — | — | CN | disclosed |
| CN-111662310-A | Preparation method and application of thiazole ring derivative | 尚会霞 | 2020-09-15 | — | — | CN | disclosed |
| EP-2513071-B1 | THIAZOLEDERIVATES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2015-06-17 | — | — | EP | disclosed |
| EP-1715840-B1 | KERATIN DYEING COMPOSITIONS CONTAINING BICYCLIC FUSED 5-5 HETEROAROMATIC DYES | PROCTER & GAMBLE (US) | 2008-12-03 | — | — | EP | disclosed |
| US-7303590-B2 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2007-12-04 | — | — | US | disclosed |
| CN-1917849-A | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER & GAMBLE (US) | 2007-02-21 | — | — | CN | disclosed |
| US-20050193502-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER, GAMBLE COMPANY, THE | 2005-09-08 | — | — | US | disclosed |