Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.35 |
| ▸ | STARD10 | Q9Y365 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032545 | 0.87 | CYP3A4 (0.44) | CYP3A4PCTPSTARD10CNR1CNR2 | |
| SCHEMBL5032495 | 0.87 | CYP3A4 (0.51) | CYP3A4PCTPSTARD10CNR1CNR2 | |
| SCHEMBL5039043 | 0.85 | CYP3A4 (0.46) | CYP3A4PCTPSTARD10CNR1CNR2 | |
| SCHEMBL14190184 | 0.83 | CYP3A4 (0.42) | CYP3A4PCTPSTARD10SLC6A2SLC6A4 | |
| SCHEMBL5032684 | 0.82 | CYP3A4 (0.52) | CYP3A4CNR1CNR2NPC1RAB9A | |
| SCHEMBL5035943 | 0.81 | CYP3A4 (0.47) | CYP3A4CNR1CNR2NPC1RAB9A | |
| SCHEMBL5035297 | 0.81 | CYP3A4 (0.43) | CYP3A4PCTPSTARD10CYP11B1CYP11B2 | |
| SCHEMBL5038792 | 0.80 | CYP3A4 (0.47) | CYP3A4PCTPSTARD10CNR1CNR2 | |
| SCHEMBL5034824 | 0.80 | CYP3A4 (0.42) | CYP3A4PCTPSTARD10CNR1CNR2 | |
| SCHEMBL5032607 | 0.79 | CYP3A4 (0.48) | CYP3A4CNR1CNR2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |