Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035261 | 0.94 | KDM4E (0.52) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5034903 | 0.92 | MAPK1 (0.52) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5036036 | 0.92 | KDM4E (0.51) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5039222 | 0.89 | MAPK1 (0.68) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5034931 | 0.88 | MAPK1 (0.51) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5032652 | 0.88 | KDM4E (0.44) | KMT2AKDM4EHTTMAPK1ALDH1A1 | |
| SCHEMBL5039150 | 0.88 | KDM4E (0.54) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5044948 | 0.87 | MAPK1 (0.64) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5034977 | 0.87 | KDM4E (0.52) | KMT2AKDM4EHTTMAPK1TP53 | |
| SCHEMBL5039093 | 0.86 | KDM4E (0.49) | KMT2AKDM4EHTTMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |